High-Fructose Corn Syrup Fuels Colon Cancer Growth in Mice



High-fructose corn syrup might sustain colon cancer growth, a minimum of in mice, a brand-new research study discovers.


In the research study, released the other day (March 21) in the journal Science, scientists discovered that taking in the equivalent of 12 ounces of a drink sweetened with high-fructose corn syrup sped up tumor growth in mice that were inclined to colon cancer.


Still, since the research study was done in mice, more research study is required to see if the findings use to people. However “our findings in animal designs recommend that persistent intake of sweet beverages can reduce the time it takes [colon] cancer to establish,” research study co-senior author Dr. Jihye Yun, an assistant teacher of molecular and human genes at Baylor College of Medication in Houston, stated in a declaration. Yun carried out the work as a postdoctoral fellow at Weill Cornell Medication in New York City City.


The scientists kept in mind that there’s been an increase in colorectal cancer rates amongst youths in current years — throughout the very same time that intake of sugar-sweetened drinks has actually increased. If the brand-new outcomes show real for people too, the findings may assist describe this link. [7 Odd Things That Raise Your Risk of Cancer (and 1 That Doesn’t)]


The research study likewise recommends possible methods to reverse the tumor-promoting results of high-fructose corn syrup, the authors stated.


Previous research studies in individuals have actually connected intake of sweet beverages with weight problems, and weight problems in turn is related to an increased threat of establishing colon cancer. However whether sugar itself might promote tumor growth was uncertain.


To analyze this concern, the scientists relied on a mouse design for colon cancer. In these mice, a gene called APC is erased, which inclines them to establishing polyps, the early phases of colon cancer. This design resembles what takes place in people — more than 90 percent of individuals with colorectal cancer likewise have anomalies in the APC gene, the authors stated.


When these mice were offered water sweetened with high-fructose corn syrup, they established colon growths that were bigger and advanced than mice who were offered simply water. The tumor-enhancing result of high-fructose corn syrup was seen even in mice that weren’t overweight.


Lead research study author Dr. Marcus Goncalves, an assistant teacher of medication at Weill Cornell Medication, kept in mind in the declaration that the research study didn’t “show that giving high-fructose syrup causes new tumors, because these mice develop tumors even on normal diets free of added sugar … But when you give them this additional sugar, the tumors grow much bigger.”


And the mice didn’t need to take in big quantities of high-fructose corn syrup to establish bigger growths — this result was seen when the mice taken in the equivalent of one can of soda (12 ounces) a day.


The scientists likewise discovered that the mouse growths easily took in both glucose and fructose. Within the growths, an enzyme called KHK (ketohexokinase) altered fructose into a substance called fructose-1-phosphate, which promotes the production of fats needed for tumor growth; and likewise makes it much easier for the growths to utilize glucose for energy.


The findings recommend that drugs that target KHK in growth cells might reverse the tumor-enhancing results of high-fructose corn syrup, the authors stated.


However what about sweeteners besides high-fructose corn syrup? Initial experiments recommend that included table sugar has the very same result in these mice, the authors stated.


Dr. Patrick Boland, an assistant teacher of oncology and intestinal oncologist at Roswell Park Comprehensive Cancer Center in Buffalo, New York City, who was not included with the research study, kept in mind that previous research study has actually discovered a link in between intake of “high glycemic” foods and sugar-sweetened drinks and greater rates of colon cancer reoccurrence and death. (High glycemic foods, consisting of high-fructose corn syrup, release sugar rapidly into the blood stream.)


“This study provides some potential explanation as to why large amounts of high-fructose corn syrup may not be good for our health in general and specifically as it relates to colon cancer,” Boland informed Live Science. “We already have data suggesting individuals with colon cancer or those at risk should probably limit the number of sugary drinks they have as much as possible,” and the brand-new research study supports this, he stated.


Still, the findings aren’t conclusive. “I do not believe we have difficult evidence to state that all sugar ought to be prevented or that [high-fructose corn syrup] ought to never ever be taken in,” Boland stated. “Many things we see in mice aren’t seen in humans.”


Extra research study taking a look at the result of sweet beverages on colon cancer in individuals would be useful, he stated.


Initially released on Live Science.



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