Optical imager poised to improve diagnosis and treatment of dry eye disease


The Tear Movie Imager records a raw image (a) and likewise produces a density map (b) originated from the color info at each pixel. This can be utilized to differentiate the tear movie’s inner layers. Credit: AdOM Advanced Optical Techniques Ltd.

Scientists have actually established a brand-new non-invasive optical imaging system that guarantees to improve diagnosis and treatments for dry eye disease. Dry eye, which typically triggers inflammation and blurred vision, takes place when there is instability in the inner layer of the tear movie that secures the outdoors of the eye.


Today, the majority of cases of dry eye are detected utilizing client surveys, which might be subjective and cannot normally be utilized to determine the cause of the disease. Goal techniques for taking a look at the tear movie tend to be intrusive and cannot track fast altering characteristics, which are modified with every blink.

“Up to 60 percent of ophthalmology office visits are due to dry eye, pointing to the need for a non-invasive and highly accurate device for diagnosis in the office setting,” stated research study group leader Dr. Yoel Arieli from AdOM Advanced Optical Techniques Ltd. in Israel. “Our Tear Film Imager is the first device that can be used in the ophthalmology or optometry setting to image the tear film and distinguish its inner layers with nanometer resolution.”

In the Optical Society (OSA) journal Applied Optics, scientists explain the gadget’s capability to carry out spectral measurements throughout a big field of view in a matter of seconds. They report that the imager can get quickly and constant measurements from human eyes even when blinking.

The research study was carried out at AdOM Advanced Optical Techniques lab. The evidence of principle, special technique and style that make it possible for measurement of ultra-thin tear layers with nanometer resolution were established by AdOM’s advancement group led by Dr. Yoel Cohen.

Improving diagnosis through imaging

“For the diagnosis of dry eye disease, there have been few significant advancements over recent years,” stated Dr. Arieli. “We collaborated with academic and practicing physicians who diagnose and treat dry eye to develop an instrument that can be integrated into a clinical setting while very accurately imaging the tear film inner layers, which can be used to diagnose dry eye and understand its cause.”

The brand-new instrument utilizes an eye-safe halogen light to brighten the eye and then evaluates the complete spectrum of light reflection in time and space. These spectral measurements are utilized to rebuild the structures discovered in the front of the eye, enabling precise measurement of the tear movie inner layers, particularly the liquid sublayer. This sublayer plays an essential function in dry eye however has actually been hard to evaluate with other techniques.

“The broadband illumination source and fine details available from spectral analysis provide nanometer-level insight into subtle changes in each tear film layer and sublayer,” stated Dr. Arieli. “These measurements are completed automatically in just 40 seconds.”

After showing a resolution of 2.2 nanometers on a mock tear movie, the scientists checked the instrument’s capability to take measurements on the human eye without any intervention while the client was blinking. “The device worked impressively and presents no risk because it is non-invasive and uses a simple light source,” stated Dr. Arieli. “It not only measured the tear film consistently including blinks every few seconds, but the measurements correlated well with other partially invasive, established dry eye diagnostic techniques.”

The Tear Movie Imager has actually been utilized in 2 scientific research studies in Israel and Canada, taking a look at dry eye diagnosis with the gadget and dry eye treatments, which can be exactly assessed with the imager. The scientists state that future research studies might assist notify much better dry eye treatments, improve surgical results and lead to more precise fitting of contact lenses. They are likewise preparing to utilize the Tear Movie Imager in bigger research studies with more varied groups of clients to set base levels for both healthy eyes and individuals with dry eye.


Contact lens pain connected to modifications in lipid layer of tear movie


More info:
Yoel Cohen et al, Tear movie imager for vibrant mapping of the human tear movie, Applied Optics (2019). DOI: 10.1364/AO.58.007987

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The Optical Society

Citation:
Optical imager poised to improve diagnosis and treatment of dry eye disease (2019, October 4)
recovered 6 October 2019
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