New way to wrap liquid drops could improve drug delivery


IMAGE: PhD trainee Sirshendu Misra, lead scientist on the advancement of new encapsulation technology, operating in the Micro Nano-Scale Transport Lab at the University of Waterloo.
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Credit: BRIAN CALDWELL

Researchers have actually established a quicker, less expensive way to coat liquid medication, a creation that could improve how drugs are provided in the body.

The new encapsulation technology, established by engineers at the University of Waterloo, utilizes gravity and other natural forces to wrap drops as they fail a thin layer of liquid shell drifting on a base liquid.

Once solidified, or treated, by direct exposure to ultraviolet light, the shell homes and secures the liquid core inside.

“It is a very simple technique that requires almost no energy – and it is extremely rapid,” stated Sushanta Mitra, executive director of the Waterloo Institute for Nanotechnology. “Encapsulation takes place in milliseconds.”

When the liquid core is needed – after reaching a specific location of the body for targeted drug delivery, for example – the shell is developed to liquify and launch its contents.

Mitra stated the system’s simpleness allows a lot more affordable production of pills than present approaches, that include devices that wrap drops with thin gel sheets and complicated microfluidic procedures.

“We envision a very simple, rapid, mass-production system using syringes,” stated Mitra, a teacher of mechanical and mechatronics engineering who is cross-appointed in chemical engineering and physics and astronomy. “With a one-shot approach, you could produce thousands of these encapsulations.”

Other benefits of the technology consist of the capability to coat drops with numerous layers, higher versatility in regards to drop volume and shell products, and the production of more powerful, more steady pills.

In addition to the targeted delivery of pharmaceuticals and vitamins, possible usages for the liquid-liquid covering approach consist of the production of small pills to include flavours to soda pop beverages as they’re being taken in and extending the life span of cosmetic creams including collagen.

Mitra monitored the research study including engineering college student Sirshendu Misra and Kumari Trinavee, and postdoctoral fellow Naga Siva Kumar Gunda.

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A paper on their work, Encapsulation with an interfacial liquid layer: Robust and effective liquid-liquid wrapping, appears in the Journal of Colloid and Interface Science.

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