Women with single dose of HPV vaccine gain similar protection as multiple doses

IMAGE: Study authors Ashish Deshmukh, PhD, MPH; and Kalyani Sonawane, PhD.
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Credit: Photo by Maricruz Kwon/UTHealth

A brand-new research study exposed that a person dose of the HPV vaccine might avoid infection from the possible cancer-causing infection, according to research study released in JAMA Network Open from The University of Texas Health Science Center at Houston (UTHealth).

According to the Centers for Disease Control (CDC), 34,800 brand-new cancer medical diagnoses are connected to human papillomavirus (HPV) every year. The infection is believed to represent more than 90% of all cervical and anal cancers, more than 60% of all penile cancers, and around 70% of all oral cancers.

While outcomes of the paper revealed that a single dose might be as efficient as the presently advised 2- or 3-dose series, it’s prematurely for individuals to depend on a single dose of the vaccine for protection, according to senior author Ashish A. Deshmukh, PhD, MPH, an assistant teacher at UTHealth School of Public Health.

“HPV vaccine coverage is less than 10% globally because of poor vaccine uptake rates in many resource-limited countries. Ensuring boys and girls receive their first dose is a big challenge in several countries and a majority of adolescents are not able to complete the recommended series due to a lack of intensive infrastructure needed to administer two or three doses,” Deshmukh stated. “If ongoing clinical trials provide evidence regarding sustained benefits of a one-dose regimen, then implications of single-dose strategy could be substantial for reducing the burden of these cancers globally.”

Although the research study individuals consisted of just women, the CDC advises a 2-dose routine for all kids beginning the series prior to age 15 or a 3-dose routine if the series is begun in between ages 16 to 26. The most recent generation of HPV vaccine can safeguard versus almost 90% of cancer-causing HPV infections. Yet, present vaccinations rates are less than perfect – half of individuals in the U.S. are not immunized versus this typical sexually transmitted infection.

“The current HPV vaccine dosing regimen can be cumbersome for people to understand. If one dose is proven effective in trials, the vaccine regimen will be simplified. This will help improve the coverage rate among adolescents that are currently below the Healthy People 2020 goal and possibly will also increase the momentum of uptake in the newly approved age group,” stated lead author Kalyani Sonawane, PhD, who is an assistant teacher at UTHealth School of Public Health.


Michael D. Swartz, PhD, of UTHealth co-authored the research study, along with Alan G. Nyitray, PhD, of the Medical College of Wisconsin; and Gizem S. Nemutlu, PhD, and Jagpreet Chhatwal, PhD, from Harvard Medical School.

Research was supported by the National Cancer Institute of the National Institutes of Health (R01CA232888). The material is entirely the duty of the authors and does not always represent the main views of the NIH.

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